Regular cleaning: The best way to keep cobwebs out of corners is by dusting and vacuuming regularly. This removes spiders and their webs. And when those variables are eliminated, cobwebs can't form. Vinegar: Distilled white vinegar is great for everything from cleaning the shower to keeping spiders away.Removing the webs that are on the exterior of your home is an excellent way to minimize the likelihood that spiders will find their way into your home soon, but other steps are also required. For example, your doors and windows should be properly sealed. A fresh sealant may be required annually for the best results.